10-23-2019  3:44 am   •   PDX Weather    •   SEA weather  
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NORTHWEST NEWS

Washington State Ecology Director Objects to EPA’s Proposed Clean Water Act Rule

Ecology Director Maia Bellon submitted formal objections in which she calls the proposal ill-advised and illegal

Washington State to Vote on Affirmative Action Referendum

More than two decades after voters banned affirmative action, the question of whether one's minority status should be considered in state employment, contracting, colleges admissions is back on the ballot

Merkley Introduces Legislation that Protects Access to Health Care for Those Who Cannot Afford Bail

Under current law, individuals in custody who have not been convicted of a crime are denied Medicare, Medicaid, and veterans’ benefits

New County Hire Aims to Build Trust, Transparency Between Community and Public Safety Officials

Leneice Rice will serve as a liaison focused on documenting and reporting feedback from a community whose faith in law enforcement has been tested

NEWS BRIEFS

U.S. Census Bureau Hosts Job Recruitment Events in Portland

There are several opportunities to ‘Meet the Employer’ today through Saturday for more information or to apply for 2020 census...

GFO Offers African Americans Help in Solving Family Mysteries

The Genealogical Forum of Oregon is holding an African American Special Interest Group Saturday, Oct. 19 ...

Third Annual NAMC-WA Gala Features Leader on Minority Business Development

The topic of the Washington Chapter of the National Association of Minority Contractors' event was 'Community and Collaboration' ...

Building Bridges Event Aims to Strengthen Trust Between Communities

The 4th Annual Building Bridges of Understanding in Our Communities: Confronting Hate will be held in Tigard on...

The Black Man Project Kicks Off National Tour in Seattle

The first in a series of interactive conversations focused on Black men and vulnerability takes place in Seattle on October 25 ...

Woman sues Oregon clinic over claims of past abuse by doctor

PORTLAND, Ore. (AP) — A woman who says she was repeatedly sexually abused by her pediatrician has filed a jumi million lawsuit against the doctor's former medical clinic in Oregon.The Oregonian/OregonLive reported Tuesday that the woman says the abuse occurred in the 1980s and early 1990s at...

Police: Body found is missing university student

PORTLAND, Ore. (AP) — Portland police say a body found near the St. Johns Bridge in Northwest Portland is a missing University of Portland freshman.Police on Tuesday evening said that the medical examiner's office had conducted an autopsy and positively identified the body as Owen...

AP Top 25: Ohio State jumps Clemson to 3rd; Wisconsin falls

Ohio State edged past Clemson to No. 3 in The Associated Press college football poll and Wisconsin dropped to 13th after being upset ahead of its showdown with the Buckeyes.Alabama remained No. 1 on Sunday in the AP Top 25 presented by Regions Bank, receiving 24 first-place votes. No. 2 LSU held...

Vaughn scores twice, Vandy upsets No. 22 Missouri 21-14

NASHVILLE, Tenn. (AP) — Derek Mason wants it known he's the best coach for the Vanderbilt Commodores.Riley Neal came off the bench and threw a 21-yard touchdown to Cam Johnson with 8:57 left, and Vanderbilt upset No. 22 Missouri 21-14 on Saturday with a stifling defensive...

OPINION

Atatiana Jefferson, Killed by Police Officer in Her Own Home

Atatiana Jefferson, a biology graduate who worked in the pharmaceutical industry and was contemplating becoming a doctor, lived a life of purpose that mattered ...

“Hell No!” That Is My Message to Those Who Would Divide Us 

Upon release from the South African jail, Nelson Mandela told UAW Local 600 members “It is you who have made the United States of America a superpower, a leader of the world" ...

Rep. Janelle Bynum Issues Response to the Latest Statement from Clackamas Town Center

State legislator questions official response after daughter questioned for ‘loitering’ in parking lot ...

Why Would HUD Gut Its Own Disparate Impact Rule?

"You can’t expand housing rights by limiting civil protections. The ’D’ in HUD doesn’t stand for ‘Discrimination’" ...

AFRICAN AMERICANS IN THE NEWS

Trump claim brings new pain to relatives of lynching victims

MONTGOMERY, Ala. (AP) — Willie Edwards Jr., a black truck driver, was killed by Ku Klux Klansmen who forced him to jump off a bridge in Alabama in 1957. Two years earlier, white men had bludgeoned black teenager Emmett Till to death in Mississippi. No one went to prison for either...

Farewells to US Rep. Elijah Cummings to begin in Baltimore

BALTIMORE (AP) — Constituents, friends and other mourners are set to gather at a historically black college in Baltimore to honor the life of U.S. Rep. Elijah Cummings in the first of a series of planned services.The Maryland congressman and civil rights champion died Thursday of...

Trump 2020 targeting Hispanic vote in nontraditional places

YORK, Pa. (AP) — President Donald Trump's reelection campaign is making contrarian appeals in the most unusual places, trying to win over Hispanic voters in states not known for them, like Pennsylvania.His second campaign, far better financed and organized than his first, is pressing every...

ENTERTAINMENT

Liam Gallagher talks solo rise, family feud and rock music

LOS ANGELES (AP) — Spend a few minutes with Liam Gallagher and it's clear the rocker hasn't lost any of his bravado, right down to counting himself among the greats in rock history.But Gallagher does acknowledge that one band breakup — not, Oasis, but rather the demise of Beady Eye in...

Lori Loughlin, other parents charged again in college scheme

BOSTON (AP) — "Full House" actress Lori Loughlin, her fashion designer husband and nine other parents faced new federal charges Tuesday in a scandal involving dozens of wealthy parents accused of bribing their children's way into elite universities or cheating on college entrance exams.A...

Celebrities to get drag makeovers in RuPaul's new VH1 series

LOS ANGELES (AP) — RuPaul is giving a dozen celebrities the chance to get drag makeovers for charity and bragging rights.VH1 said Tuesday that "RuPaul's Celebrity Drag Race" will air as a limited series next year.Each of the four episodes will feature a trio of stars competing for best drag...

U.S. & WORLD NEWS

Soto, Nationals top Cole, Astros 5-4 in World Series opener

HOUSTON (AP) — Juan Soto and the Washington Nationals quickly derailed the Cole Express.A 20-year-old...

39 people found dead in truck container in southeast England

LONDON (AP) — Police in southeastern England said 39 people were found dead Wednesday inside a truck...

Trump 2020 targeting Hispanic vote in nontraditional places

YORK, Pa. (AP) — President Donald Trump's reelection campaign is making contrarian appeals in the most...

Botswana votes as ruling party faces surprising challenge

GABORONE, Botswana (AP) — Polls opened in Botswana on Wednesday as the long-peaceful southern African...

UK prime minister mulls early election over Brexit impasse

LONDON (AP) — British Prime Minister Boris Johnson was weighing Wednesday whether to push for an early...

Putin aims to boost Moscow's clout with Russia-Africa summit

MOSCOW (AP) — Russian President Vladimir Putin hosted dozens of leaders of African nations Wednesday for...

McMenamins
Malcom Ritter AP Science Writer


Dr. Anthony Fauci, director of
the National Institute of Allergy
and Infectious Diseases

NEW YORK (AP) -- As scientists struggle to find a vaccine to prevent infection with the AIDS virus, a study in mice suggests hope for a new approach - one that doctors now want to test in people.

The treated mice in the study appeared to have 100 percent protection against HIV. That doesn't mean the strategy will work in people. But several experts were impressed.

"This is a very important paper (about) a very creative idea," says the government's AIDS chief, Dr. Anthony Fauci. He didn't take part in the research.

The new study involved injecting mice with a protective gene, an idea that's been tested against HIV infection in animals for a decade.

In the nearly 30 years since HIV was identified, scientists haven't been able to find a vaccine that is broadly effective. One boost came in 2009, when a large study in Thailand showed that an experimental vaccine protected about a third of recipients against infection. That's not good enough for general use, but researchers are now trying to improve it.

Researchers reported the new results in mice online Wednesday in the journal Nature. They hope to test the approach in people in a couple of years. Another research team reported similar success in monkeys in 2009 and hopes to start human tests even sooner.

A traditional vaccine works by masquerading as a germ, training the body's immune system to build specific defenses in case the real germ shows up. Those defenses are generally antibodies, which are proteins in the blood that have just the right shape to grab onto parts of an invading virus. Once that happens, the virus can't establish a lasting infection and is cleared from the body.

Scientists have identified antibodies that neutralize a wide range of HIV strains, but they've had trouble getting people's immune systems to create those antibodies with a vaccine.

The gene-injection goal is straightforward. Rather than trying to train a person's immune system to devise effective antibodies, why not just give a person genes for those proteins? The genes can slip into cells in muscle or some other tissue and make them pump out lots of the antibodies.

The mouse work is reported by David Baltimore and colleagues at the California Institute of Technology.

Ordinary mice don't get infected with HIV, which attacks the immune system. So the research used mice that carried human immune system cells.

Baltimore's team used a harmless virus to carry an antibody gene and injected it once into a leg muscle. The researchers found that the mice made high levels of the antibody for more than a year. The results suggest lifetime protection for a mouse, Baltimore said, although "we simply don't know what will happen in people."

Even when the mice were injected with very high doses of HIV, they didn't show the loss of certain blood cells that results from HIV infection. Baltimore said researchers couldn't completely rule out the possibility of infection, but that their tests found no evidence of it. He said a few hundred mice appeared to be protected.

The work was funded by the federal government and the Bill and Melinda Gates Foundation. Baltimore said his lab has filed for patents.

"I think it's great," said Dr. Philip R. Johnson of the Children's Hospital of Philadelphia, who reported similar results in monkeys in 2009. "It provides additional evidence this is a concept that's worth moving forward."

Johnson said he has discussed doing a human trial with federal regulators and is preparing an application for permission to go ahead. If all goes well, a preliminary experiment to test the safety of the approach might begin in about a year, he said. Baltimore said his group is also planning human experiments that he hopes will start in the next couple years.

Fauci, who is director of the National Institute of Allergy and Infectious Diseases, cautioned that mouse results don't always pan out in human studies. He also said both the gene approach and standard vaccines should be pursued because it's not clear which will work better.

"We're still in the discovery stage of both of them," he said.

Dr. Harris Goldstein, director of the Einstein-Montefiore Center for AIDS Research in New York, who has done similar research in mice, called Baltimore's result a significant advance if it works in humans because it shows a single injection produces high levels of antibodies for a long time.

It might lead not only to preventing infection, but also a treatment for infected people, he said. If it allowed people with HIV to stop or reduce their medications even for temporary periods, they could avoid the inconvenience and side effects of the drugs, he said.

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Online:

Nature: http://www.nature.com/nature

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Malcolm Ritter can be followed at http://twitter.com/malcolmritter .

© 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed. Learn more about our Privacy Policy and Terms of Use.

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