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Portland Street Response Hosts Town Hall
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Georgia ends game on 12-0 run to beat Missouri 64-59 in first round of SEC tourney
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Georgia faces Missouri in SEC Tournament
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COMMENTARY: Is a Cultural Shift on the Horizon?
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Key findings from AP's investigation into police force that isn't supposed to be lethal
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Why did more than 1,000 people die after police subdued them with force that isn't meant to kill?
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Celebrity birthdays for the week of March 31-April 6
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How to make an Easter ham last all week
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Russian veto brings end to UN panel monitoring enforcement of North Korea nuclear sanctions
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Pope, looking strong, washes feet of 12 women at Rome prison from his wheelchair
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King Charles stresses importance of kindness as he skips pre-Easter service amid cancer treatment
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Few American adults with sickle cell anemia are getting a recommended medication that can help them manage pain, breathing problems and other debilitating symptoms, according to a new study.
Using a national database, researchers found that less than one-quarter of sickle cell patients who should have been taking a drug called hydroxyurea actually were.
“This is a medication that’s highly beneficial and yet most people aren’t getting it,” said George Buchanan, MD, a sickle cell expert, and a professor at the University of Texas Southwestern Medical Center at Dallas, who was not involved in the new study.
Findings from the study were reported in the April 28 issue of the Journal of the American Medical Association.
Sickle cell anemia is an inherited disease that mainly affects people of African, South American or Mediterranean descent. In the United States, about one in 500 African American children are born with the condition, according to the U.S. National Heart, Lung, and Blood Institute (NHLBI).
Experts contend that the central problem in sickle cell is that the body produces red blood cells that are crescent-shaped, rather than disc-shaped. Those abnormal cells tend to be sticky and can block blood flow—causing symptoms such as fatigue and shortness of breath.
Many people with sickle cell also suffer sudden bouts of pain due to poor blood flow. And according to treatment guidelines released last year, adults who have three or more pain “crises” within a year should be prescribed hydroxyurea.
Hydroxyurea was originally developed as a cancer drug, but it treats sickle cell by prompting the body to make fetal hemoglobin—an oxygen-carrying protein in red blood cells. That, in turn, helps keep red blood cells from becoming stiff, sticky and crescent-shaped, according to the NHLBI.
“My own view is, the vast majority of people with sickle cell anemia should be taking hydroxyurea,” said Buchanan, who helped develop the latest treatment guidelines.
He added that people who work in the field have long known that hydroxyurea is underused, but this study offers hard numbers.
“The findings are not surprising, but they’re very disappointing,” Buchanan said.
So why aren't more people who need it getting the drug? There are several issues, said Michael DeBaun, MD, who directs the sickle cell treatment center at Vanderbilt University in Nashville, Tenn.
For one, DeBaun explained, there are few hematologists who specialize in treating sickle cell patients—especially adults. So people with the disease often see only a primary care doctor.
But because sickle cell is relatively rare, DeBaun said, most primary care doctors have little experience treating it.
Add to that the fact that they may know little about hydroxyurea.
“It’s a cancer drug,” DeBaun said, “and most internists do not go through their training learning how to manage a chemotherapy agent.”
Another issue, DeBaun said, is that many sickle cell patients are low-income Blacks. Some may be uninsured or “under-insured,” and possibly have no consistent health provider. Plus, they often live in areas, whether rural or urban, that lack specialists in the disease, DeBaun explained.